Dang near every news source is reporting the shoot down of Malaysian Air MH17 over the Ukraine. It’s reported that 295 souls were on board.
Airliners fly at 30,000 feet or more, so this wasn’t a simple shoulder launched missile, but a larger radar guided surface to air missile. Some reports say it was a “Buk” missile system, but of course, with all the finger pointing going on, there’s no way to be sure.
Recently, pro-Russian separatists in eastern Ukraine have claimed to have shot down a couple of Ukrainian military aircraft, including one at an altitude above MANPADS range. It’s likely that they also shot down MH17.